Ni ibihe biranga ikoreshwa rya Glabridin, ifite ingaruka nziza zo kwera kurusha Vitamine C na Niacinamide?

Cyari kizwi nka "izahabu ihindura ibara ry'umweru", kandi izina ryacyo riri mu ngaruka zacyo zidasanzwe zo guhindura ibara ry'umweru ku ruhande rumwe, no ku rundi ruhande, ingorane n'ubuke bw'ikoreshwa ryacyo. Ikimera Glycyrrhiza glabra ni isoko ya Glabridin, ariko Glabridin igizwe na 0.1%-0.3% by'ibiyigize muri rusange, ni ukuvuga ko 1000kg ya Glycyrrhiza glabra ishobora kubona garama 100 gusa.Glabridin, 1g ya Glabridin ingana na 1g ya zahabu isanzwe.
Hikarigandine ni ikintu gisanzwe kigize ibimera, kandi ingaruka zayo zo kwera zavumbuwe n'Ubuyapani
Glycyrrhiza glabra ni ikimera cyo mu bwoko bwa Glycyrrhiza. Ubushinwa ni cyo gihugu gifite ibimera bikungahaye cyane ku isi, kandi hari ubwoko burenga 500 bw'ibimera bikoreshwa mu buvuzi, muri byo ikikoreshwa cyane ni licorice. Dukurikije imibare, igipimo cy'ikoreshwa rya licorice kiri hejuru ya 79%.
Bitewe n'amateka maremare yo gukoreshwa, hamwe n'izina rikomeye, ubushakashatsi ku gaciro ka licorice ntibwanyuze gusa mu mipaka y'ubutaka, ahubwo bwanagutse. Dukurikije ubushakashatsi, abaguzi bo muri Aziya, cyane cyane mu Buyapani, bubaha cyane amavuta yo kwisiga arimo ibimera bikora. Ibintu 114 byo kwisiga byanditswe mu "Ibikoresho by'Ubuhinde bya Cosmetics", kandi hari ubwoko 200 bw'amavuta yo kwisiga arimo ibimera mu Buyapani.

Bizwi ko bigira ingaruka nziza cyane ku kwera, ariko se ni izihe ngorane mu ikoreshwa ryayo?

Igice cy’umusemburo wa licorice giterwa n’amazi kirimo ubwoko butandukanye bwa flavonoids. Nk’igice cy’ingenzi cy’igice cyayo giterwa n’amazi, halo-glycyrrhizidine igira ingaruka ku ikorwa rya melanin kandi ikagira ingaruka ku kubyimba no kurwanya okiside.
Amakuru amwe n'amwe y'ubushakashatsi agaragaza ko ingaruka z'urumuri rwa Glabridin ziyongera ku nshuro 232 kurusha iza vitamine C isanzwe, inshuro 16 kurusha iza hydroquinone, n'inshuro 1.164 kurusha iza arbutin. Ku bijyanye n'uburyo bwo kugera ku musaruro ukomeye w'urumuri, Glabridin itanga uburyo butatu butandukanye.

1. Kubuza imikorere ya tyrosinase
Uburyo bw'ingenzi bwo kwezaGlabridinni ukubuza ikorwa rya melanin binyuze mu kugabanya imikorere ya tyrosinase mu buryo buhanitse, gukuraho igice cya tyrosinase mu ruziga rw’ikorwa rya melanin no kubuza ko substrate ifatana na tyrosinase.
2. Ingaruka zo kurwanya ogisijeni
Ishobora kubuza imikorere ya tyrosinase na dopa pigment exchange ndetse n'imikorere ya dihydroxyindole carboxylic acid oxidase.
Byagaragaye ko ku gipimo cya 0.1mg/ml, photoglycyrrhizidine ishobora gukora kuri sisitemu ya oxidation ya cytochrome P450/NADOH no gukuraho 67% bya radicals yigenga, ifite imikorere ikomeye ya antioxydant.

3. Kubuza ibintu bitera ubushyuhe no kurwanya imirasire y'izuba
Muri iki gihe, ubushakashatsi buke bwaragaragaye ku ikoreshwa rya photoglycyrrhizidine mu bushakashatsi ku ruhu ruterwa na UV. Mu 2021, mu nkuru yasohotse mu kinyamakuru shingiro cya Journal of Microbiology and Biotechnology, liposomes za photoglycyrrhizidine zakoreweho ubushakashatsi ku bushobozi bwazo bwo koroshya erythema iterwa n'urumuri rwa UV n'indwara z'uruhu binyuze mu gukumira ibintu bitera ubushyuhe. Liposomes za photoglycyrrhizidine zishobora gukoreshwa mu kunoza uburyo umubiri ubonekamo hamwe n'uburozi buke hamwe no gukumira melanin neza, bigabanye neza igaragara rya cytokines zitera ubushyuhe, interleukin 6 na interleukin 10. Kubwibyo, ishobora gukoreshwa nk'umuti wo kuvura mu rwego rwo kurwanya kwangirika k'uruhu guterwa n'imirasire ya UV binyuze mu gukumira ubushyuhe, bishobora gutanga ibitekerezo bimwe na bimwe mu bushakashatsi ku bikoresho birinda imirasire y'izuba.
Muri make, ingaruka zo kwera za photoglycyrrhizidine zirazwi, ariko imiterere yazo ubwayo ntishobora gushonga mu mazi, bityo ikaba isaba cyane cyane uburyo bwo gukora no gushyira mu bikorwa ibikoresho byo kwita ku ruhu, kandi ubu ni igisubizo cyiza binyuze mu ikoranabuhanga rya liposome encapsulation. Byongeye kandi, ifotoGlabridinLiposomes zishobora gukumira ifoto iterwa n'imiraba ya UV, ariko iyi mikorere ikeneye igerageza ryinshi rya muganga kugira ngo ryemezwe kandi hashyirwe mu bikorwa ubushakashatsi.

Ibikoresho byo kwita ku ruhu birimo photoGlabridin mu buryo bwo guhuza ibintu.

Nubwo nta gushidikanya ko photoGlabridine igira ingaruka nziza cyane zo kwera, igiciro cyayo cy’ibikoresho fatizo nacyo ni kinini bitewe n’ingorane zo gukuramo no gukoresha. Mu bushakashatsi no Guteza Imbere ubwiza, akazi ko kugenzura ibiciro gafitanye isano itaziguye n’ikoranabuhanga n’uburyo bwa siyansi. Kubwibyo, ni uburyo bwiza bwo kugenzura ikiguzi cy’imiti no kugera ku bwiza butekanye mu guhitamo ibintu bikora no kubivanga mu guteranya na photoglycyrrhizidine. Byongeye kandi, ku rwego rw’ubushakashatsi no Guteza Imbere, hakenewe ubushakashatsi bw’inyongera ku birebana n’ubushakashatsi ku marasomu ya photoglycyrrhizidine n’uburyo bugezweho bwo kuyikuramo.