Ni diydrocoumarin uburozi

DIHYDROCOUMARIN, impumuro nziza, ikoreshwa mu biribwa, nayo ikoreshwa nka gare ya coumarin, ikoreshwa nkibintu byoroshye; Kuvanga, cocout, uburyohe bwa cinnamon; Byakoreshejwe kandi nk'ubutaka bw'itabi.

Ni diydrocoumarin uburozi

Diydrocoumarin ntabwo ari uburozi. Diydrocoumarin nigicuruzwa gisanzwe kiboneka muri knilla rhinos. Bitegurwa na hydrogenation ya coumarin imbere ya Nikel Catalistst kuri 160-200 ℃ no ku gitutu. Irashobora kandi gukoreshwa nkibikoresho fatizo, hydrolyzed mu gisubizo cya alkaline cyo gutanga o-hydroxyphenyonyonlprosionic acide, umwuma, gufunga-loacle yabonetse.

Imiterere

Gufunga kandi umwijima, ubitswe ahantu hakonje kandi humye, umwanya uri muri barrile ni muto bishoboka mu nshingano z'umutekano, kandi zuzuye uburiganya bwazo. Kubika mu bubiko bukonje, buhumeka. Irinde umuriro, amazi. Igomba kubikwa ukundi kuva kuri Oxidizer, ntugavange ububiko. Ifite ibikoresho bitandukanye hamwe nubunini bwibikoresho byumuriro.

Mu myigire ya vitro

Muri Vitro Enzymatic Assay, Diahdrocoumarin yashidikajweho-kwibanda kwibanda kuri Sirt1 (IC50 ya 208μm). Kugabanuka mu bikorwa bya Deacetylase byagaragaye ndetse no kuri micrommolar dosiye (85 ± 5.8 na 73 ± 13,7% kuri 1.6μm na 8μm,). Microtubule SURT2 Deacetylase nayo yabujijwe muburyo busa (IC50 ya 295μm).

Nyuma yamasaha 24 yo kwerekana, diymdrocoumarin (1-5mm) yiyongereye cytotoxigine mumirongo ya TK6 muburyo bushingiye kuri Dose. Diydrocoumarin (1-5mm) kongeramo apoptose mumirongo ya TK6 muburyo bushingiye ku gipimo kumwanya wamasaha 6. Igipimo cya 5mm cya diymdrocoumarin kongeramo apoptose mumwanya wamasaha 6 yerekeza kumurongo wa TK6. Nyuma yigihe cyamasaha 24 yo kwerekana, diymmrocoumarin (1-5mm) yiyongereye p53 lysine 373 na 382 acetylation muburyo butunzwe mumurongo wa tk6.