Chlorphenesine

Chlorphenesine(104-29-0), izina ry'imiti ni 3-(4-chlorophenoxy)propane-1,2-diol, muri rusange ikorwa binyuze mu buryo p-chlorophenol ikorana na propylene oxide cyangwa epichlorohydrin ikora. Ni umuti urwanya udukoko twinshi kandi urwanya bagiteri, ugira ingaruka ku mikorobe za Gram-positive, bagiteri za Gram-negative, imisemburo n'ibihumyo. Yemejwe gukoreshwa mu kwisiga n'ibihugu byinshi n'uturere nka Burayi, Leta Zunze Ubumwe za Amerika, Ubuyapani, n'Ubushinwa. Imikoreshereze yemewe n'amategeko n'amabwiriza menshi y'igihugu ni 0.3%.
ChlorphenesineMbere ntabwo yakoreshejwe nk'umuti urinda indwara, ahubwo yakoreshejwe nk'umuti ugabanya ubudahangarwa bw'umubiri uterwa na antigen ubuza irekurwa rya histamine riterwa na IgE mu nganda zikora imiti. Muri make, irwanya allergie. Mu 1967, inganda zikora imiti zari zarize ku ikoreshwa rya chlorphenesin na penicilline mu gukumira allergie iterwa na penicilline. Ni mu 1997 gusa aho chlorphenesin yavumbuwe n'Abafaransa kubera ingaruka zayo zo kwica udukoko no kuvura bagiteri, maze ikoreshwa ku byangombwa bifitanye isano.
1. Ese chlorphenesin igabanya imitsi?
Raporo y'isuzuma yagaragaje neza ko chlorphenesin, ikintu cyo kwisiga kitagira ingaruka zo kugabanya imitsi. Kandi bivugwa kenshi muri iyo raporo: Nubwo incamake y'icyongereza y'ikintu cyo mu rwego rw'imiti chlorphenesin n'ikintu cyo kwisiga chlorphenesin byombi ari Chlorphenesin, byombi ntibikwiye kwitiranywa.
2. Ese chlorphenesin itera uruhu kurakara?
Byaba ku bantu cyangwa ku nyamaswa, chlorphenesin nta ruhu igira ububabare ku rugero rusanzwe, kandi si ikintu gituma uruhu rubyimba cyangwa ngo rube urumuri. Hari ingingo enye cyangwa eshanu gusa zivuga ku makuru avuga ko chlorphenesin itera ububabare ku ruhu. Kandi hari aho chlorphenesin ikoreshwa ari 0.5% kugeza kuri 1%, irenga cyane urugero ikoreshwa mu kwisiga. Mu zindi nzira nyinshi, byavuzwe gusa ko chlorphenesin yari iri muri iyo formula, kandi nta bimenyetso byagaragaye bigaragaza ko chlorphenesin yateye dermatitis. Ukurikije ikoreshwa rikomeye rya chlorphenesin mu kwisiga, aya mahirwe ntarengwa.
3. Ese chlorphenesine izinjira mu maraso?
Igerageza ryakozwe n'inyamaswa ryagaragaje ko imwe muri chlorphenesin yinjira mu maraso nyuma yo gukora ku ruhu. Chlorphenesin nyinshi yinjijwe izahinduka mu nkari, kandi yose izava mu mubiri mu masaha 96. Ariko iyi gahunda yose ntabwo izatanga ingaruka mbi z'uburozi.
4. Ese Chlorphenescine igabanya ubudahangarwa bw'umubiri?
Ntabwo bizashoboka. Chlorphenesin ni umuti ugabanya ubudahangarwa bw’umubiri uterwa na antigen. Mbere na mbere, chlorphenesin igira uruhare runini iyo ihujwe na antigen yagenwe, kandi ntigabanya ubudahangarwa bw’umubiri, cyangwa ngo yongere umubare w’indwara. Icya kabiri, nyuma yo guhagarika gukoreshwa, ingaruka zo gukumira ubudahangarwa bw’umubiri za antigen yagenwe zizashira, kandi nta ngaruka zirambye zizabaho.
5. Umwanzuro wa nyuma w'isuzuma ry'umutekano ni uwuhe?
Hashingiwe ku mikoreshereze isanzweho n'uburyo ikoreshwa muri Leta Zunze Ubumwe za Amerika (wash-off 0.32%, resident type 0.30%), FDA yemera kochlorphenesineni umuti urinda indwara zo mu maso.