Imiti ya Pharmacodynamic ya Chloroxylenol

Chloroxylenol, cyangwa para-chloro-meta-xylenol (PCMX), ni antibacterial izwi cyane kandi igabanya ubukana.Nibikoresho byogusukura bikoreshwa mubitaro byibitaro kugirango bisukure ibikoresho byo kubaga.

Chloroxylenol ni kimwe mu bintu bifatika bikoreshwa mu gukora amasabune ya antiseptic.Na none, porogaramu zayo zaciwe mu buvuzi no mu rugo nka disinfectant.

Dukurikije urutonde rw’umuryango w’ubuzima ku isi urutonde rw’imiti y’ibanze, indwara ya chloroxylenol yandura indwara ya bagiteri izwi ku izina rya Gram-positif, yanditse neza.

Ariko, ukeneye imiti myiza ya antibacterial na disinfectant kugirango urugo rwawe nibitaro bikeneye, noneho ugomba kuvugana numuntu uzwichloroxylenoluruganda.

Kwerekana imiti ya Chloroxylenol

Porogaramu ya Chloroxylenol ivugwa neza murwego rwubuvuzi.

Yabanje gukoreshwa mu kuvura indwara zuruhu nko gushushanya, gukata, kurumwa n’inyamaswa, gukomeretsa, hamwe n’isuku ryamaboko.

Pharmacodynamic ya Chloroxylenol

Chloroxylenolni insimburangingo ya phenol, bivuze ko ifite hydroxyl group mumiterere yayo.

Ikoreshwa ryayo rizwi cyane mumyaka nkimwe mubice bigize ibicuruzwa byica mikorobe.Porogaramu isabwa hanze yakagari.

Ibikorwa byayo birwanya mikorobe ku gipimo gito ku itsinda rya bagiteri.

Uburyo bwibikorwa

Kubaho kwa hydroxyl mumatsinda yayo bifite akamaro kanini, cyane cyane iyo ubushobozi bwa farumasi bugomba gusobanurwa.

Itsinda rya hydroxyl rifatwa ko ryometse kuri poroteyine zihuza, nazo zikaba zifasha mukubuza bagiteri gutera.

Chloroxylenol yinjira muri selile ya bagiteri kugirango yibasire byinshi hamwe na enzymes na proteyine zihagije.Iyo ibi bikozwe, bihagarika ibikorwa byakagari.

Bizagera ku ntera aho Chloroxylenol nyinshi ikoreshwa mu ngirabuzimafatizo zibaviramo urupfu.

Metabolism ya Chloroxylenol

Kugirango ubone ibyangombwa bya Chloroxylenol nka bagiteri na disinfectant, inyamaswa zakoreshejwe mukwiga byimazeyo ibikorwa byubushobozi bwayo.

Isuzuma ry’inyamaswa ryerekanye ko bitewe n’ikoreshwa rya dermal Chloroxylenol, umuvuduko wo kwibizwa warihuse cyane mu masaha abiri yambere.

Byagaragaye kandi ko ibintu byahawe inyamaswa byatewe inkari binyuze mu mpyiko bikuraho burundu ku muvuduko w’amasaha 24.

Ikintu cyingenzi cyagaragaye muri sample yanduye harimo glucuronide na sulfate.

Inyinshi mu ngingo zubushakashatsi zerekeye Chloroxylenol zagereranije ibikorwa byazo na antibacterial izwi cyane kandi ikunzwe cyane yitwa triclosan.Raporo yerekanye ko glucuronide nayo yari mubice by'icyitegererezo cyanduye muburyo bw'umuntu.

Ikirenzeho, uhereye ku bushakashatsi bw’icyitegererezo cy’umuntu, byafashwe ko buri mg 5 yajyanywe mu mubiri nyuma yo kwihagarika kugeza kuri 14% bya aside glucuronic na aside sulfurike mu minsi itatu.

Nyamara, ingano iyo ari yo yose ya Chloroxylenol yajyanywe muri sisitemu nyuma izajya igogorwa n'umwijima hanyuma ikarekurwa nka sulfate na glucuronic.

Inzira yo Kurandura

Nkuko bigaragara hejuru mubushakashatsi bwakozwe na Chloroxylenol bwerekana ko inzira nyamukuru chloroxylenol ikurwa muri sisitemu nyuma yubuyobozi binyuze muminkari.

Nubwo, umubare muto cyane ufatwa ko uri munda kandi muke cyane mukirere gihumeka.

Ukeneye Chloroxylenol?

Mugwanezakanda hanouyumunsi kuriChloroxylenolkubicuruzwa byawe byose birwanya antiseptike na disinfectant, kandi tuzishimira cyane gufatanya nawe kubicuruzwa byiza.