Gukoresha cinnamaldehyde mu gupfunyika ibiryo birwanya bagiteri

Cinnamaldehyde igizwe na 85% ~ 90% by'amavuta y'ingenzi ya sinamomu, kandi Ubushinwa ni bumwe mu turere duhingwamo sinamomu, kandi umutungo wa sinamomu ukungahaye kuri cinnamaldehyde. Imiterere ya molekile ya Cinnamaldehyde (C9H8O) ni itsinda rya phenyl rihujwe na acrylein, mu buryo busanzwe bw'amazi y'umuhondo cyangwa umuhondo, afite uburyohe bwihariye kandi bukomeye bwa sinamomu na coke, ashobora gukoreshwa mu birungo no mu birungo. Kuri ubu, hamaze kugaragara raporo nyinshi ku ngaruka za cinnamaldehyde ku mikorere ya antibacterial ya spectrum nini n'imikorere yayo, kandi ubushakashatsi bwagaragaje ko cinnamaldehyde ifite ingaruka nziza za antibacterial kuri bagiteri na fungi. Mu rwego rw'ubuvuzi, ubushakashatsi bumwe na bumwe bwasuzumye iterambere ry'ubushakashatsi bwa cinnamaldehyde mu ndwara za metabolisme, indwara z'imitsi igendana n'amaraso, kurwanya kanseri n'ibindi bintu, kandi bwasanze cinnamaldehyde ifite uburyo bwiza bwo kurwanya diyabete, kurwanya umubyibuho ukabije, kurwanya kanseri n'ibindi bikorwa bya farumasi. Kubera ko ifite amasoko menshi, ibintu karemano, umutekano, uburozi buke, uburyohe bwihariye n'ingaruka za antibiyotike ku buryo bugari, ni inyongeramusaruro y'ibiribwa yemewe n'Ikigo gishinzwe ibiribwa n'imiti cya Leta Zunze Ubumwe za Amerika n'Ubushinwa. Nubwo ingano ntarengwa yayo idahagaze mu ikoreshwa ryayo, guhinduka kwayo no guhumeka kwayo bigabanya ikoreshwa ryayo mu biribwa. Gushyira cinnamaldehyde mu gapapuro ko gupfunyikamo ibiryo bishobora kunoza ubushobozi bwayo bwo kurwanya antibiyotike no kugabanya ingaruka zayo ku biryo, kandi bikagira uruhare mu kunoza ubwiza bw'ibiryo no kubitwara no kongera igihe cyo kubibika.

1. Matrix y'urukiramende rw'imiti irwanya bagiteri

Ubushakashatsi bwinshi ku firime yo gupfunyika ibiryo ikoresha imiti irwanya udukoko ikoresha imiti irwanya udukoko ikoresha imiti isanzwe n’ishobora kwangirika nk’umuti ukoreshwa mu gupfunyika, kandi firime yo gupfunyika itegurwa hakoreshejwe uburyo bwo gusiga, gutwika cyangwa uburyo bwo gusohora ubushyuhe bwinshi. Bitewe n’uburyo butandukanye bwo gukora no guhuza hagati y’uduce dutandukanye tw’urukiramende n’ibintu bikora, imiterere y’urukiramende iratandukanye, bityo ni ngombwa cyane guhitamo substrate ikwiye y’urukiramende. Substrate zikoreshwa cyane mu gupfunyika zirimo ibintu bishobora kwangirika nk’inzoga ya polyvinyl na polypropylene, ibintu karemano nka polysaccharides na poroteyine, n’ibintu bivanze. Polyvinyl alcohol (PVA) ni polimeri isanzwe, isanzwe ikora imiterere y’urukiramende ifite imiterere itatu iyo ihujwe, kandi ifite imiterere myiza ya mekanike n’imiterere y’imbogamizi. Umutungo kamere umeze nk’urukiramende uboneka ku bwinshi kandi uturuka ahantu henshi. Urugero, aside polylactic ishobora gushongeshwa mu bikoresho fatizo nka sitashi n’ibigori, bifite amasoko ahagije kandi ashobora kongera gukoreshwa, bishobora kwangirika neza kandi bihura neza n’ibinyabuzima, kandi ni ibikoresho byiza byo gupfunyika bifasha mu kubungabunga ibidukikije. Matrix ivanze akenshi igizwe n'uturemangingo tubiri cyangwa turenze, dushobora kugira uruhare rwuzuzanya ugereranije n'uturemangingo tubiri.

Imiterere ya mashini n'imiterere y'imbogamizi ni ibipimo by'ingenzi byo gusuzuma niba filime yo gupfunyika ikwiriye. Kongeramo cinnamaldehyde bizahuza na polymer membrane matrix bityo bigabanye fluidity ya molekile, kugabanuka k'uburebure igihe cyo gucika biterwa no kutumvikana kw'imiterere ya polysaccharide, kandi kwiyongera kw'imbaraga zo gukurura biterwa no kwiyongera kw'itsinda rikunda amazi mu gihe cyo gukora filime guterwa no kongeramo cinnamaldehyde. Byongeye kandi, impumuro ya cinnamaldehyde muri membrane ivanze ya cinnamaldehyde muri rusange yariyongereye, bishobora guterwa no gukwirakwira kwa cinnamaldehyde muri polymer kugira ngo habeho imyenge, imyanda n'imiyoboro, kugabanya imbaraga zo kohereza amazi, ndetse amaherezo bigatuma impumuro ya cinnamaldehyde muri membrane ivanze ya cinnamaldehyde yiyongera. Imiterere ya mashini n'impumuro ya membrane nyinshi zivanze bisa, ariko imiterere n'imiterere ya substrate zitandukanye za polymer biratandukanye, kandi uburyo butandukanye bwo gukorana na cinnamaldehyde bigira ingaruka ku mikorere ya filime yo gupfunyika, hanyuma bigira ingaruka ku ikoreshwa ryayo, bityo ni ngombwa cyane guhitamo substrate ya polymer ikwiye n'ubwinshi bwayo.

Icya kabiri, uburyo bwo gufatanya cinnamaldehyde n'ipaki

Ariko, cinnamaldehyde ishongera gato mu mazi ifite ubushobozi bwo gushonga bwa 1.4 mg/mL gusa. Nubwo ikoranabuhanga ryo kuvanga ryoroshye kandi ryoroshye, ibyiciro bibiri bya cinnamaldehyde ishongera amavuta n'umuvuduko ukabije w'amazi ntibihindagurika, kandi ubushyuhe bwinshi n'imiterere y'umuvuduko mwinshi bikunze kuba ngombwa mu gukora filime bigabanya cyane ubwinshi bwa cinnamaldehyde iboneka mu membrane. Biragoye kugera ku ngaruka nziza ya bagiteri. Ikoranabuhanga ryo gushyiramo ni uburyo bwo gukoresha ibikoresho byo ku rukuta kugira ngo upfunyike cyangwa winjizemo ikintu gikenewe gushyirwamo kugira ngo utange inkunga y'imikorere cyangwa uburinzi bwa shimi. Gukoresha ikoranabuhanga ryo gushyiramo kugira ngo ushyiremo cinnamaldehyde mu bikoresho byo gupfunyika bishobora gutuma irekurwa buhoro, kongera umuvuduko wo kugumana, kongera igihe cyo gusaza kwa filime, no kunoza imiterere ya filime yo gupfunyika. Kuri ubu, uburyo busanzwe bwo kubaka cinnamaldehyde n'ifilime yo gupfunyika bushobora kugabanywamo ibice bibiri: kubaka cinnamaldehyde n'imashini yo gupfunyika, harimo polymer embedding, nano liposome embedding, cyclodextrin embedding, nano ibumba rihambira cyangwa umutwaro. Binyuze mu guhuza uburyo bwo kwihuza no gukora electrospinning, icyuma gitanga cinnamaldehyde gishobora kunozwa, kandi uburyo bwo gukora n'uburyo cinnamaldehyde ikoreshwamo bushobora kunozwa.

Gukoresha agapapuro k'ibiryo gapfunyikamo sinamoni aldehyde

Ubwoko butandukanye bw'ibiribwa bufite ingano itandukanye y'amazi, imiterere y'intungamubiri n'uburyo bwo kubibika no gutwara, kandi imiterere y'imikorobe yononekara iratandukanye cyane. Ingaruka zo kubika imiti irwanya bagiteri ya cinnamaldehyde ku biribwa bitandukanye nazo ziratandukanye.

1. Ingaruka zo kubika neza imboga n'imbuto

Ubushinwa bukungahaye ku mutungo kamere, muri byo umusaruro n'isoko ry'imboga n'imbuto ni byinshi. Ariko, ubushuhe n'isukari by'imboga n'imbuto biri hejuru, bikungahaye ku ntungamubiri, kandi bikunze kwanduza mikorobe no kwangirika mu gihe cyo kubika, gutwara no kugurisha. Kuri ubu, gukoresha agapapuro ko gupfunyikamo antibacterial ni uburyo bw'ingenzi bwo kunoza ubwiza bw'imboga n'imbuto no kongera igihe cyo kuzitwara. Agapapuro ko gupfunyikamo pome gafite aside polylactic composite gashobora kugabanya igihombo cy'intungamubiri, kubuza rhizopus gukura, no kongera igihe cyo kubika pome kugeza ku minsi 16. Iyo agapapuro ko gupfunyikamo ibiribwa gakozwe na cinnamaldehyde gashyirwa ku ipaki ya karoti nshya, gukura kw'ibihumyo n'umusemburo byarakumirwaga, igipimo cyo kubora kw'imboga cyaragabanutse, kandi igihe cyo kubikwamo cyongerwa kugeza ku minsi 12.

2. Ingaruka nziza ku nyama zikomoka ku nyama Ibiryo by'inyama bikungahaye kuri poroteyine, ibinure n'ibindi bintu, bikungahaye ku ntungamubiri n'uburyohe bwihariye. Mu bushyuhe bw'icyumba, kororoka kwa mikorobe bituma poroteyine z'inyama, karubohidrati n'ibinure bibora, bigatuma inyama zibora, ubuso bufatana, ibara ryijimye, kubura ubushobozi bwo guhindagurika, n'impumuro mbi. Cinnamaldehyde active food packing film ikoreshwa cyane mu gupakira ingurube n'amafi, ahanini ibuza gukura kwa Staphylococcus aureus, Escherichia coli, aeromonas, umusemburo, bagiteri za aside lactic n'izindi bagiteri, kandi ishobora kongera igihe cyo kumara iminsi 8 kugeza 14.

3. Ingaruka zo kubika neza ibikomoka ku mata. Muri iki gihe, ikoreshwa ry'ibikomoka ku mata mu Bushinwa ririyongera buri mwaka. Foromaje ni ibikomoka ku mata byasembuye bifite intungamubiri nyinshi na poroteyine. Ariko foromaje imara igihe gito, kandi igipimo cy'imyanda mu bushyuhe buke kiracyateye impungenge. Gukoresha agapapuro k'ibiribwa ka cinnamic aldehyde bishobora kongera igihe cyo kubika foromaje, bigatuma foromaje irushaho kuryoha, kandi bikarinda kwangirika kwa foromaje. Ku duce twa foromaje n'isosi ya foromaje, igihe cyo kubika foromaje cyongerwa kugeza ku minsi 45 n'iminsi 26 nyuma yo gukoresha paki ikora ya cinnamaldehyde, ibyo bikaba byiza mu kuzigama umutungo.

4. Ingaruka nziza zo kubika ibiryo by’ibirayi bishya ni ibikomoka kuri ibirayi bikozwe mu ifu y’ingano, ipamba yoroshye ya pinusi, biryoshye kandi biraryoshye. Ariko, umugati na keke bimara igihe gito kandi bishobora kwanduzwa n’ibihumyo mu gihe cyo kugurisha, bigatuma ubuziranenge bw’ibiryo bugabanuka kandi bigasesagura ibiryo. Gukoresha cinnamaldehyde mu gupfunyika ibiryo mu ifu ya siponji n’umugati uciwe bishobora kubuza gukura no gukwirakwira kwa penicillium n’ibihumyo by’umukara, kandi bikongera igihe cyo kubikwa kugeza ku minsi 10 ~ 27, uko bikurikirana.

 

Cinnamaldehyde ifite ibyiza byo kuba iboneka mu bwinshi, ifite bagiteri nyinshi kandi ifite uburozi buke. Nk'ikintu gitera bagiteri mu gupakira ibiryo, cinnamaldehyde ihamye kandi irekurwa buhoro buhoro bishobora kunozwa binyuze mu kubaka no kunoza uburyo bwo gutwara ibiryo, ibyo bikaba bifite akamaro kanini mu kunoza uburyo ibiryo bibikwa n'uburyo byo gutwara ibiryo bishya no kongera igihe cyo kubibika. Mu myaka ya vuba aha, cinnamaldehyde yageze ku bikorwa byinshi n'iterambere mu bushakashatsi bwo kubika ibiryo, ariko ubushakashatsi bujyanye n'ibyo buracyari mu ntangiriro, kandi haracyari ibibazo bimwe na bimwe bigomba gukemurwa. Binyuze mu bushakashatsi bugereranya ingaruka z'uburyo butandukanye bwo gutwara ibiryo ku miterere ya mekanike n'imiterere y'imbogamizi z'ururenda, gusesengura byimbitse uburyo cinnamaldehyde n'uburyo bwo kubisohora hamwe n'uburyo birekurwa mu bidukikije bitandukanye, kwiga ingaruka z'itegeko ry'iterambere ry'udukoko mu biribwa ku kwangirika kw'ibiryo, n'uburyo bwo kugenzura uburyo bwo gupakira bagiteri ku gihe n'umuvuduko wo kurekura imiti yica udukoko. Gushushanya no guteza imbere uburyo bwo gupakira bushobora kuzuza ibisabwa bitandukanye byo kubika ibiryo.